Flocoumafen

CAS NO.：90035-08-8
Empirical Formula: C33H25F3O4
Molecular Weight: 542.54
MDL number: MFCD01662724
EINECS: 421-960-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-10 10:27:23

What is Flocoumafen?

The Uses of Flocoumafen

Flocoumafen is a second-generation anti-coagulant used as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the United Kingdom). This restriction is mainly due to the increased risk to non-target species. Studies have shown that rodents resistant to first-generation anti-coagulants can be adequately controlled with flocoumafen. The chemical substance is off-white solid, does not mix well with water (1.1 mg/L), and is sparingly soluble in acetone, ethanol, xylene, and octanol. Flocoumafen is stable to hydrolysis. Because of the acute toxicity of flocoumafen and its intended use as a rodenticide, chronic toxicity studies have not been reported. However, flocoumafen is known to cause adverse health effects and abnormal prothrombin.

The Uses of Flocoumafen

Flocoumafen is used to control rodents around buildings. It also has some use in field and plantation crops including cocoa, cotton, oilpalm, rice and sugar cane.

What are the applications of Application

Flocoumafen is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type

Definition

ChEBI: Flocoumafen is a ring assembly, a member of naphthalenes and a member of benzenes.

Metabolic pathway

Flocoumafen exists as cis and trans isomers (Scheme 1). The tetralin ring adopts its most stable conformation in each case and the two forms have very similar shapes. Both are active rodenticides. The fate of flocoumafen in soils and plants has not been studied in detail because the compound is usually used as a pelleted bait or in a wax block. This limits its dissipation in the environment. Studies in animals and birds have been conducted as part of the assessment of safety and to investigate mode of action. Metabolism is slow in the rat and rapid in Japanese quail but this difference should be interpreted with care because of the 100-fold difference in dose used (see also Overview).

Degradation

Flocoumafen is a stable compound; no detectable degradation occurs at 50 °C at pH 7-9 over 4 weeks.

Properties of Flocoumafen

Melting point:	181 °C
Boiling point:	672.4±55.0 °C(Predicted)
Density	1.2 g/cm3
vapor pressure	1.33 x l0^-10 Pa (25 °C)
Flash point:	23 °C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	neat
pka	4.50±1.00(Predicted)
Water Solubility	1.1 mg l^-1
form	Solid
color	White to off-white
EPA Substance Registry System	2H-1-Benzopyran-2-one, 4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1-naphthalenyl]- (90035-08-8)

Safety information for Flocoumafen

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection.