FLICE

CAS NO.：179241-78-2
Molecular Weight: 0
MDL number: MFCD01865996
Update Date: 2026-05-28 02:47:21

What is FLICE?

General Description

Human recombinant C?terminal histidine tagged caspase 8 is expressed as the truncated pro-caspase 8 (amino acids 213?496). It is a fully active protein consisting of 18 kDa and 12.4 kDa subunits; the 12.4 kDa subunit contains the histidine tag.

Biochem/physiol Actions

Caspase 8 is at the top of the hierarchy of the caspase cascade and is considered an initiator caspase. It exists in the cell as an inactive 55?kDa proenzyme. It is converted to the active form, consisting of 18?kDa and 11?kDa subunits, upon its recruitment to the cytoplasmic domain of activated death receptors such as CD95 or TNFR via the adapter protein FADD. The activation of the proenzyme is triggered by the protein′s aggregation, which leads to auto- or transprocessing. Caspase?8 activates downstream caspases (caspases?3, 6, and 7) that cleave key cellular substrates and lead to apoptotic death of the cells.

Properties of FLICE

storage temp.	−70°C
form	buffered aqueous solution

Safety information for FLICE

Computed Descriptors for FLICE

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