FIIN-2

CAS NO.：1633044-56-0
Empirical Formula: C35H38N8O4
Molecular Weight: 634.73
MDL number: MFCD28386553
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is FIIN-2?

Description

FIIN-2 is an irreversible FGFR inhibitor with IC₅₀ values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2. By inhibiting FGFR in a zebrafish developmental model, FIIN-2 caused mild to severe alterations in tail morphogenesis similar to the phenotypes reported following genetic knockdown of FGFR.

The Uses of FIIN-2

FIIN 2 is FGFR inhibitor. It can be used in biological study of DFG-out mode of inhibition by an irreversible Type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors

Properties of FIIN-2

Density	1.306±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥31.75 mg/mL in DMSO; insoluble in H2O; ≥3.39 mg/mL in EtOH with gentle warming
form	solid
pka	13.51±0.70(Predicted)
color	White to off-white

Safety information for FIIN-2

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for FIIN-2

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