FHD-286

CAS NO.：2671128-05-3
Empirical Formula: C24H30N6O6S2
Molecular Weight: 562.66
Update Date: 2026-05-25 21:30:47

What is FHD-286?

Description

FHD-286 is a highly potent, selective, allosteric and orally available, small-molecule, enzymatic inhibitor of BRG1 (SMARCA4) and BRM (SMARCA2), two highly similar proteins that are the ATPases, or the catalytic engines of the BAF complex, one of the critical regulators within the chromatin regulatory system. In preclinical studies, FHD-286 has shown anti-tumour activity across a broad range of malignancies, including hematologic and solid tumours. FHD-286 is being developed for relapsed and/or refractory AML.

Properties of FHD-286

Density	1.46±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (444.32 mM; Need ultrasonic)
form	Solid
pka	7.18±0.50(Predicted)
color	Off-white to light yellow

Safety information for FHD-286

Computed Descriptors for FHD-286

InChIKey	JBLQNFBXKOAIHG-FCEWJHQRSA-N
SMILES	N1(S(C)(=O)=O)C=CC(C(N[C@@H](COC)C(NC2=NC(C3=NC(N4C[C@H](C)O[C@H](C)C4)=CC=C3)=CS2)=O)=O)=C1

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