Fexofenadine-d10 Hydrochloride
- CAS NO.：1215821-44-5
- Empirical Formula: C32H29D10NO4.ClH
- Molecular Weight: 548.18
- Update Date: 2025-08-20 16:56:25
What is Fexofenadine-d10 Hydrochloride?
Description
Fexofenadine-d10 is intended for use as an internal standard for the quantification of fexofenadine by GC- or LC-MS. Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine . Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; ).
The Uses of Fexofenadine-d10 Hydrochloride
Fexofenadine-d10 Hydrochloride is the labeled analogue of Fexofenadine Hydrochloride (F322490), the active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.
Properties of Fexofenadine-d10 Hydrochloride
| Melting point: | 150-155°C |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for Fexofenadine-d10 Hydrochloride
Computed Descriptors for Fexofenadine-d10 Hydrochloride
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