FENOBAM

Synonym(s):N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea

CAS NO.：57653-26-6
Empirical Formula: C11H11ClN4O2
Molecular Weight: 266.68
MDL number: MFCD00868019
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 08:30:42

What is FENOBAM?

Description

During the 1970s and 1980s, researchers at McNeil Laboratories synthesized fenobam from creatine and developed it as an anxiolytic drug. Its molecular target was unknown at the time, but in 2005 fenobam was discovered to be a potent, selective mGluR5?antagonist. This finding prompted structure–activity relationship studies with fenobam as the lead compound. Among other potential uses, it may lead to a treatment for autism.

The Uses of FENOBAM

Fenobam is a potent and selective non-competitive mGluR5 antagonist.

The Uses of FENOBAM

Sedative-hypnotic.

What are the applications of Application

Fenobam is a potent and selective non-competitive mGluR5 antagonist

Storage

Room temperature

Properties of FENOBAM

Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO: >20mg/mL
pka	8.32±0.20(Predicted)
form	solid
color	white

Safety information for FENOBAM

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H300:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P233:Keep container tightly closed. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304:IF INHALED: P312:Call a POISON CENTER or doctor/physician if you feel unwell. P321:Specific treatment (see … on this label). P330:Rinse mouth. P340:Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362:Take off contaminated clothing and wash before reuse. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P403:Store in a well-ventilated place. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…