FD-IN-1
- CAS NO.：1646682-14-5
- Empirical Formula: C23H23NO4
- Molecular Weight: 377.43
- MDL number: MFCD32067952
- Update Date: 2026-07-27 17:00:41
What is FD-IN-1?
Biological Activity
FD-IN-1 (Compound 12) is a potent, orally active complement factor D (FD) inhibitor with IC50 of 12 nM.It also inhibits factor XIa (FXIa) and tryptase β2 with IC50 of 7.7 and 6.5 μM, respectively.
in vitro
FD-IN-1 (Compound 12) exhibits functional inhibition of AP activation (IC 50 =0.26 μM) in vitro in a membrane attack complex (MAC) deposition assay using 50% human whole blood (WB).
in vivo
FD-IN-1 (Compound 12) demonstrates systemic suppression of AP activation in a lipopolysaccharide-induced alternative complement pathway (AP) activation model as well as local ocular suppression in intravitreal injection-induced AP activation model in mice expressing human FD.
FD-IN-1 (Compound 12) exhibits high oral bioavailability (C57BL6 mice 83%, Beagle dogs 70%) following oral administration (mice and dogs 10 mg/kg).
FD -IN-1 (Compound 12) exhibits terminal elimination half-lives (C57BL6 mice 1.6 h and Beagle dogs 3.8 h) following intravenous administration (mice and dogs 1 mg/kg).
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| Animal Model: | Human FD knock-in mice |
| Dosage: | 3 and 10 mg/kg |
| Administration: | Oral gavage |
| Result: | The AP pathway was fully inhibited for up to 10 h at the 10 mg/kg dose. |
| Boiling point: | 629.4±55.0 °C(Predicted) |
| Density | 1.251±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 4.14±0.10(Predicted) |
| color | White to off-white |
Safety information for FD-IN-1
Computed Descriptors for FD-IN-1
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