FBDP

The Uses of FBDP

• Tyrosine-selective bioconjugation reagent for the incorporation of a bioorthogonal aldehyde into peptides, proteins, antibodies or cell surfaces.
• The aldehyde can then be reacted with a variety of bioconjugation, labeling or detection reagents containing hydrazine/hydrazide or oxyamine functionalities.
• FBDP is a novel development in the field of Tyr bioconjugation as it is bench-stable as opposed to prevoius diazonium reagents that require in situ preparation.
• FBDP has been shown to modify small molecules, peptides, proteins and living cell surface proteins in high yields.
• The labeling proceeds quickly with common reaction times of 30 min at room temperature at pH 7-8 (slightly higher yield and selectivity seen at pH 8).