FASCAPLYSIN CHLORIDE

Synonym(s):Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem

CAS NO.：114719-57-2
Empirical Formula: C18H11ClN2O
Molecular Weight: 306.74574
MDL number: MFCD09752600
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is FASCAPLYSIN CHLORIDE?

Description

Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

The Uses of FASCAPLYSIN CHLORIDE

Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.

What are the applications of Application

Fascaplysin is a selective CDK4/cyclin D1 inhibitor

References

1) Soni?et al. (2000),?Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun.,?275?877 2) Lin?et al. (2007),?Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol.,?59?439 3) Hamilton?et al. (2014),?Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs,?12?1377

Properties of FASCAPLYSIN CHLORIDE

storage temp.	2-8°C
solubility	Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
form	solid
color	Dark red-brown
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.