ETOFYLLINE CLOFIBRATE

Originator

Duolip,Merckle,W. Germany,1981

The Uses of ETOFYLLINE CLOFIBRATE

Duolip (L. Merckle, Germany).

What are the applications of Application

Etofylline clofibrate is an antioxidant shown to lower blood lipid levels

Definition

ChEBI: Etofylline clofibrate is an oxopurine.

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic