ETHYLTHIOUREA

The Uses of ETHYLTHIOUREA

N-Ethylthiourea was used in the preparation of Re (III) complexes, which are precursors for the new rhenium complexes, potentially useful in nuclear medicine. It was also used in two-step protocol for the first chemoselective cleavage of 2-hydroxy acid amides

What are the applications of Application

Ethylthiourea is a bactericidal precursor

Definition

ChEBI: N-ethylthiourea is a member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by an ethyl group. It is functionally related to a thiourea.

General Description

N-Ethylthiourea forms adduct with silver halides and their single crystal X-ray structural and spectroscopic characterizations are described.

Biological Activity

Potent, selective and reversible inhibitor of isoform II NO synthase (IC 50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).

Safety Profile

Poison by ingestion. SYN: 1-ETHYLTHIOUREA Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Sox and NOx.

Purification Methods

Crystallise the thiourea from EtOH, MeOH or ether. [Beilstein 4 IV 374.]