Ethyl 5-nitroindole-2-carboxylate
- CAS NO.：16732-57-3
- Empirical Formula: C11H10N2O4
- Molecular Weight: 234.21
- MDL number: MFCD00216477
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:13:45
What is Ethyl 5-nitroindole-2-carboxylate?
Chemical properties
yellow to brown powder
The Uses of Ethyl 5-nitroindole-2-carboxylate
Ethyl 5-Nitroindole-2-carboxylate is used as a reagent in the synthesis of indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Ethyl 5-Nitroindole-2-carboxylate is also a useful synthetic intermediate in the synthesis of Delavirdine (D230625) which is a bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor.
Properties of Ethyl 5-nitroindole-2-carboxylate
| Melting point: | 220-225 °C |
| Boiling point: | 376.52°C (rough estimate) |
| Density | 1.3240 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | Powder |
| pka | 13.26±0.30(Predicted) |
| color | Yellow to brown |
| Water Solubility | negligible |
| CAS DataBase Reference | 16732-57-3(CAS DataBase Reference) |
Safety information for Ethyl 5-nitroindole-2-carboxylate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Ethyl 5-nitroindole-2-carboxylate
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