Ethyl 3,3-Diethoxypropionate

Synonym(s):Malonaldehydic acid ethyl ester diethylacetal

CAS NO.：10601-80-6
Empirical Formula: C9H18O4
Molecular Weight: 190.24
MDL number: MFCD00009865
EINECS: 234-223-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-09 17:45:08

What is Ethyl 3,3-Diethoxypropionate?

Description

Ethyl 3,3-diethoxypropionate is an organic compound that is synthesized from the reaction of diethyl malonate and chloroacetic acid in the presence of a base catalyst. This product has been shown to be an effective inhibitor of mitochondrial cytochrome c oxidase in vitro studies. Ethyl 3,3-diethoxypropionate also has been found to inhibit quinoline derivatives, such as erythromycin and tetracycline, which are involved in bacterial DNA synthesis. Furthermore, this product inhibits β-unsaturated aldehydes and allylation.

Chemical properties

clear colorless liquid

The Uses of Ethyl 3,3-Diethoxypropionate

Ethyl 3,3-diethoxypropionate participates in the Yb(OTf)3 catalyzed synthesis of dihydropyridines (DHPs).

Synthesis Reference(s)

The Journal of Organic Chemistry, 47, p. 2216, 1982 DOI: 10.1021/jo00132a055
Synthesis, p. 274, 1988 DOI: 10.1055/s-1988-27541

Properties of Ethyl 3,3-Diethoxypropionate

Melting point:	200-202 °C
Boiling point:	92-93 °C/13 mmHg (lit.)
Density	0.978 g/mL at 25 °C (lit.)
refractive index	n20/D 1.411(lit.)
Flash point:	184 °F
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
color	Clear colorless
BRN	1772110
Stability:	Hygroscopic
InChI	InChI=1S/C9H18O4/c1-4-11-8(10)7-9(12-5-2)13-6-3/h9H,4-7H2,1-3H3
CAS DataBase Reference	10601-80-6(CAS DataBase Reference)

Safety information for Ethyl 3,3-Diethoxypropionate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…