Ethyl 2-chloroacetoacetate
Synonym(s):2-Cl-ACE
- CAS NO.：609-15-4
- Empirical Formula: C6H9ClO3
- Molecular Weight: 164.59
- MDL number: MFCD00009141
- EINECS: 210-180-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-08 10:32:36
What is Ethyl 2-chloroacetoacetate?
Chemical properties
clear bright yellow liquid
The Uses of Ethyl 2-chloroacetoacetate
Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae.
Biochem/physiol Actions
Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity.
Synthesis
Using ethyl acetoacetate and thionyl chloride as raw materials, the condensation reaction is carried out in the presence of a solvent. The dosage ratio of ethyl acetoacetate, thionyl chloride, and solvent is 1:1.37~2.75:2.31~4.62 by mass, the temperature of the condensation reaction is 75~95°C, and the reaction time is 5.5-9h. After stopping the reaction, evaporate most of the solvent and unreacted thionyl chloride under normal pressure, and then distill the remaining organic phase under reduced pressure to collect the 107-108°C/1.87kPa fraction to obtain Ethyl 2-chloroacetoacetate Products. The solvents used were n-heptane or, dichloroethane or toluene.
Hazard
Ethyl 2-chloroacetoacetate is harmful if ingested, causing burns and tear soreness; inhalation may cause corrosive damage to the upper respiratory tract.
Properties of Ethyl 2-chloroacetoacetate
| Melting point: | -80 °C |
| Boiling point: | 107 °C/14 mmHg (lit.) |
| Density | 1.19 g/mL at 25 °C (lit.) |
| vapor pressure | 49.4-100Pa at 20℃ |
| refractive index | n |
| Flash point: | 122 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Liquid |
| pka | 7.92±0.46(Predicted) |
| color | Clear yellow |
| Water Solubility | 17 g/L (20 ºC) |
| BRN | 774278 |
| CAS DataBase Reference | 609-15-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Butanoic acid, 2-chloro-3-oxo-, ethyl ester(609-15-4) |
| EPA Substance Registry System | Ethyl 2-chloroacetoacetate (609-15-4) |
Safety information for Ethyl 2-chloroacetoacetate
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H302:Acute toxicity,oral H314:Skin corrosion/irritation H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for Ethyl 2-chloroacetoacetate
Ethyl 2-chloroacetoacetate manufacturer
NSR Amino Organics
1Y
Phone:+91-9866989891
Whatsapp: +91-9866989891
product: Ethyl-2-Chloroacetoacetate 98%
Sri Haimavathi Organics
Hyderabad
product: Ethyl-2- Chloroacetoacetate, For Api Intermediates, Grade: Commercial
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