ETAZOLATE

Chemical properties

Off-White Solid

The Uses of ETAZOLATE

Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.

The Uses of ETAZOLATE

PDE inhibitor

The Uses of ETAZOLATE

An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.

Definition

ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).