ETAZOLATE
Synonym(s):1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;SQ 20009
- CAS NO.：51022-77-6
- Empirical Formula: C14H19N5O2
- Molecular Weight: 289.33
- MDL number: MFCD00600136
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is ETAZOLATE?
Chemical properties
Off-White Solid
The Uses of ETAZOLATE
Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.
The Uses of ETAZOLATE
PDE inhibitor
The Uses of ETAZOLATE
An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.
Definition
ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.
Biological Activity
Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).
Properties of ETAZOLATE
| Melting point: | 193-194°C |
| Boiling point: | 427.6±55.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | H2O: >20 mg/mL Solutions should be freshly prepared. |
| form | solid |
| pka | 9.94±0.70(Predicted) |
| color | white |
| CAS DataBase Reference | 51022-77-6 |
Safety information for ETAZOLATE
Computed Descriptors for ETAZOLATE
New Products
1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one Cis-Tosylate Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D BENZENE-D6 TOLUENE-D3 2-Hydroxybutanenitrile 1-Benzylindolin-2-one Ethyl 2-bromo-3-oxobutanoate 4-(3-chloropropyl)morpholine 1-Benzylindoline-2,3-dione 3-Oxocyclobutanecarboxylic acid 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](https://img.chemicalbook.in/CAS/GIF/952182-02-4.gif)
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