ETAZOLATE
Synonym(s):1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;SQ 20009
- CAS NO.：51022-77-6
- Empirical Formula: C14H19N5O2
- Molecular Weight: 289.33
- MDL number: MFCD00600136
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is ETAZOLATE?
Chemical properties
Off-White Solid
The Uses of ETAZOLATE
Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.
The Uses of ETAZOLATE
PDE inhibitor
The Uses of ETAZOLATE
An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.
Definition
ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.
Biological Activity
Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).
Properties of ETAZOLATE
| Melting point: | 193-194°C |
| Boiling point: | 427.6±55.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | H2O: >20 mg/mL Solutions should be freshly prepared. |
| form | solid |
| pka | 9.94±0.70(Predicted) |
| color | white |
| CAS DataBase Reference | 51022-77-6 |
Safety information for ETAZOLATE
Computed Descriptors for ETAZOLATE
New Products
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Pentadecanoic acid Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 5-Bromo-2-Fluoropyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 4-Bromo-3-(ethoxymethyl)benzoic acid 2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine N2-Isobutyryl-2'-O-methylguanosine 2-chloro-5-methylpyridin-4-amine 4-Bromobenzaldehyde 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one 5-Phenyl-[1,3,4]-thiadiazol-2-amineRelated products of tetrahydrofuran
![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](https://img.chemicalbook.in/CAS/GIF/952182-02-4.gif)
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