Eprazinone dihydrochloride
- CAS NO.：10402-53-6
- Empirical Formula: C24H33ClN2O2
- Molecular Weight: 416.99
- MDL number: MFCD01695215
- EINECS: 233-872-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-11 08:41:34
What is Eprazinone dihydrochloride?
Originator
Mucitux,Riom,France,1969
The Uses of Eprazinone dihydrochloride
Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.
Definition
ChEBI: A hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid.
Manufacturing Process
61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g
(0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and
0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The
product is allowed to crystallize, then filtered and washed with alcohol. It is
dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water.
Yield: 66%. Melting point: 160°C.
Therapeutic Function
Antitussive
Properties of Eprazinone dihydrochloride
| Melting point: | 201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
Safety information for Eprazinone dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Eprazinone dihydrochloride
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