Epifluorohydrin

Synonym(s):1,2-Epoxy-3-fluoropropane

CAS NO.：503-09-3
Empirical Formula: C3H5FO
Molecular Weight: 76.07
MDL number: MFCD00005131
EINECS: 207-960-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 06:14:13

What is Epifluorohydrin?

Chemical properties

clear colourless liquid

The Uses of Epifluorohydrin

Epifluorohydrin is used as a reagent in the synthesis of N-arylphosphoramidates. In addition, it is used in the synthesis of orally bioavailable ALK inhibitors in the treatment of tumors.

General Description

Clear colorless liquid.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

A halogenated epoxide. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts. The chlorinated derivative has been shown to be incompatible with aniline, strong oxidizers, sulfuric acid, isopropylamine, zinc, aluminum, iron, etc. see epichlorohydrin.

Health Hazard

ACUTE/CHRONIC HAZARDS: Epifluorohydrin is a lacrimator. When heated to decomposition it emits toxic fumes.

Fire Hazard

Epifluorohydrin is flammable.

Properties of Epifluorohydrin

Boiling point:	85-86 °C (lit.)
Density	1.067 g/mL at 25 °C (lit.)
refractive index	n20/D 1.368(lit.)
Flash point:	40 °F
storage temp.	0-6°C
color	clear
CAS DataBase Reference	503-09-3(CAS DataBase Reference)
NIST Chemistry Reference	Oxirane, (fluoromethyl)-(503-09-3)
EPA Substance Registry System	Epifluorohydrin (503-09-3)

Safety information for Epifluorohydrin

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H225:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.