Entecavir Impurity
- CAS NO.：1333204-94-6
- Empirical Formula: C12H15N5O3
- Molecular Weight: 277.28
- MDL number: MFCD11100789
- Update Date: 2023-05-04 17:34:33
What is Entecavir Impurity?
The Uses of Entecavir Impurity
(1R,3S,4S)-Entecavir is an impurity of Entecavir (E558900).
Definition
ChEBI: Entecavir (anhydrous) is guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B. It has a role as an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor and an antiviral drug. It is a member of 2-aminopurines, an oxopurine, a primary alcohol and a secondary alcohol.
Properties of Entecavir Impurity
| Boiling point: | 661.4±65.0 °C(Predicted) |
| Density | 1.81±0.1 g/cm3(Predicted) |
| pka | 14.22±0.60(Predicted) |
Safety information for Entecavir Impurity
Computed Descriptors for Entecavir Impurity
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