E-64C

Synonym(s):(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane

CAS NO.：76684-89-4
Empirical Formula: C15H26N2O5
Molecular Weight: 314.38
MDL number: MFCD00132882
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:56:45

What is E-64C?

Description

E-64c is an active metabolite of the protease inhibitor E-64d . E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml. E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.

The Uses of E-64C

E-64c is a cysteine protease inhibitor used for detecting autophagy in plants.

What are the applications of Application

E-64-c is an effective synthetic calpain inhibitor

Definition

ChEBI: E-64c is a leucine derivative.

Properties of E-64C

storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH
form	White to off-white solid
color	White to off-white

Safety information for E-64C

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.