E-64C
Synonym(s):(2S,3S)-trans-Epoxysuccinyl-L -leucylamido-3-methylbutane
- CAS NO.：76684-89-4
- Empirical Formula: C15H26N2O5
- Molecular Weight: 314.38
- MDL number: MFCD00132882
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:04
What is E-64C?
Description
E-64c is an active metabolite of the protease inhibitor E-64d . E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml. E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.
The Uses of E-64C
E-64c is a cysteine protease inhibitor used for detecting autophagy in plants.
What are the applications of Application
E-64-c is an effective synthetic calpain inhibitor
Definition
ChEBI: E-64c is a leucine derivative.
Properties of E-64C
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | ≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH |
| form | White to off-white solid |
| color | White to off-white |
Safety information for E-64C
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for E-64C
| InChIKey | SCMSYZJDIQPSDI-SRVKXCTJSA-N |
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