E-4031
Synonym(s):N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
- CAS NO.：113559-13-0
- Empirical Formula: C21H33Cl2N3O5S
- Molecular Weight: 510.47
- MDL number: MFCD00889193
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is E-4031?
The Uses of E-4031
E-4031 has been used as:
- human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
- IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
- IKr blocker in rat ventricular myocytes
What are the applications of Application
E-4031 dihydrochloride is a K+ channel blocker that spawned a class of antiarrhythmic molecules
Biological Activity
Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.
Biochem/physiol Actions
E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.
Storage
Room temperature (desiccate)
Properties of E-4031
| storage temp. | -20°C |
| solubility | H2O: soluble |
| form | solid |
| color | off-white |
| Stability: | Hygroscopic |
Safety information for E-4031
Computed Descriptors for E-4031
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 4-(4-Αminophenyl)-3-Morpholinone 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one N-cyanoacetylurethane 1H-IndazoleRelated products of tetrahydrofuran
![N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE](https://img.chemicalbook.in/CAS/GIF/25877-30-9.gif)
![1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE](https://img.chemicalbook.in/CAS/GIF/5452-83-5.gif)
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