DSHN >=98% (HPLC)

CAS NO.：313952-63-5
Empirical Formula: C15H17NO5S
Molecular Weight: 323.36
Update Date: 2026-05-22 09:14:11

What is DSHN >=98% (HPLC)?

Description

DSHN is a novel activator of small heterodimer partner (SHP, NR0B2). DSHN transcriptionally activates SHP mRNA, but also stabilizes the SHP protein by preventing its ubiquitination and degradation.

Definition

ChEBI: 5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid is a member of naphthalenes and a sulfonic acid derivative.

in vivo

DSHN transcriptionally activated Shp mRNA, but also stabilized the SHP protein by preventing its ubiquitination and degradation. Second, this study identified Ccl2 as a new SHP target gene by RNA-seq. This study showed that activation of SHP by DSHN repressed Ccl2 expression and secretion by inhibiting p65 activation of CCL2 promoter activity, as demonstrated in vivo in Shp-/- mice and in vitro in HCC cells with SHP overexpression and knockdown._x000D_ _x000D_ Reference: Mol Cancer Ther. 2016 Oct;15(10):2294-2301. https://pubmed.ncbi.nlm.nih.gov/27486225/

Properties of DSHN >=98% (HPLC)

Boiling point:	519.7±60.0 °C(Predicted)
Density	1.387±0.06 g/cm3(Predicted)
pka	2.73±0.30(Predicted)

Safety information for DSHN >=98% (HPLC)

Computed Descriptors for DSHN >=98% (HPLC)

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