Dropropizine
Synonym(s):3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
- CAS NO.：17692-31-8
- Empirical Formula: C13H20N2O2
- Molecular Weight: 236.31
- MDL number: MFCD00079124
- EINECS: 241-683-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-11-04 17:01:57
What is Dropropizine?
Originator
Ribex,Formenti
The Uses of Dropropizine
Dropropizine is a cough suppressant and central sedative therapeutic agent.
The Uses of Dropropizine
antitussive
Definition
ChEBI: 3-(4-phenyl-1-piperazinyl)propane-1,2-diol is a member of piperazines.
Manufacturing Process
34 g 1,2-epoxy-3-hydroxypropane (glycide) in 50 ml of water were added to 64.8 g 1-phenylpiperazine in 80 ml of ethanol at the temperature not higher 50°C. The mixture was stood at night, then it was evaporated to dryness in vacuum and the stark product was recrystallized from 100 ml of acetone to give 60 g 1-phenyl-4-(2,3-dihydroxypropyl)piperazine (dropropizine) MP 105°C; BP 205°C/1 mm Hg.
Therapeutic Function
Antitussive
Properties of Dropropizine
| Melting point: | 105° (Morren); mp 108° (Bourdais) |
| Boiling point: | 205 °C(Press: 1 Torr) |
| Density | 1.168±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | neat |
| pka | 14.21±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 17692-31-8(CAS DataBase Reference) |
Safety information for Dropropizine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Dropropizine
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