DROFENINE HYDROCHLORIDE
- CAS NO.：548-66-3
- Empirical Formula: C20H32ClNO2
- Molecular Weight: 353.93
- MDL number: MFCD00034983
- EINECS: 208-954-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is DROFENINE HYDROCHLORIDE?
Originator
Trasentine A,Ciba
The Uses of DROFENINE HYDROCHLORIDE
Spasmolytic
The Uses of DROFENINE HYDROCHLORIDE
Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.
Manufacturing Process
17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in
200 parts of acetic acid and hydrogenated over platinum catalyst. After the
calculated volume of hydrogen was passed, the catalyst was filtered off and
the solvent was removed to dryness. Ether, water and a potassium carbonate
solution were added to the remaining oil and were thoroughly shaken. The
ether layer was washed with water and dried over potassium carbonate. The
solvent was removed, the remaining oil was distilled in vacuum to give 2-
(diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.
Therapeutic Function
Spasmolytic
Properties of DROFENINE HYDROCHLORIDE
| Melting point: | 145-147° |
| storage temp. | 2-8°C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh |
| form | Solid |
| color | White to Off-White |
Safety information for DROFENINE HYDROCHLORIDE
Computed Descriptors for DROFENINE HYDROCHLORIDE
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