DPO-1
Synonym(s):(+)-Neomenthyl diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide
- CAS NO.：43077-30-1
- Empirical Formula: C22H29OP
- Molecular Weight: 340.44
- MDL number: MFCD09038567
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:15
What is DPO-1?
What are the applications of Application
DPO-1 is a blocker of Kv1.5 channel and IKur ultra rapid delayed rectifier potassium current
Definition
ChEBI: [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene is a monoterpenoid.
Biological Activity
Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
Storage
Store at +4°C
Properties of DPO-1
| storage temp. | Store at +4°C |
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| form | needles |
| color | white |
Safety information for DPO-1
Computed Descriptors for DPO-1
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