DOTA

Synonym(s):DOTA

CAS NO.：60239-18-1
Empirical Formula: C16H28N4O8
Molecular Weight: 404.42
MDL number: MFCD00068657
EINECS: 611-959-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:13:52

What is DOTA?

Chemical properties

Colourless crystals

The Uses of DOTA

Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.

The Uses of DOTA

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.

It has been used for radiolabeling of carbon nanotube bioconjugates by chelating ⁶⁴Cu radioisotope.
DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
It can form complexes with gadolinium for application as MRI contrast agents.
Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Definition

ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.

Properties of DOTA

Melting point:	267 °C
Boiling point:	701.6±60.0 °C(Predicted)
Density	1.321
storage temp.	Sealed in dry,Room Temperature
solubility	Water (Slightly, Heated), Methanol (Slightly)
pka	2.16±0.10(Predicted)
form	Powder
color	white
BRN	1186987
Stability:	Hygroscopic

Safety information for DOTA

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.