DJ-V159
- CAS NO.：2253744-53-3
- Empirical Formula: C24H12F6N4O2
- Molecular Weight: 502.37
- EINECS: 604-604-1
- Update Date: 2026-07-27 17:00:41
What is DJ-V159?
Description
GPRC6A? is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1?GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 (2253744-53-3) is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A. It stimulates insulin secretion in mouse β-cells and lowers blood glucose in mouse models.3
Storage
Store at RT
References
1) Pi and Quarles (2012),?Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks; Endocrinology,?153?2062 2) Pi?et al.?(2016),?GPRC6A: Jack of all metabolism (or master of none); Mol. Metab.,?6?185 3) Pi?et al.?(2018),?Computationally identified novel agonists for GPRC6A; PLoS One,?13?e0195980
Properties of DJ-V159
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 60 mg/ml). |
| form | solid |
| color | Off-white |
| Stability: | Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for DJ-V159
Computed Descriptors for DJ-V159
New Products
2-Bromo-4-hydroxypyridine Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1-aminocyclobutanecarbonitrile hydrochloride AMINO-O-TOLYL-ACETIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 3-Oxocyclobutanecarboxylic acid METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 2-(2-Bromophenyl)ethanol Boc-D-Glu(OMe)-OMe 2,5 Dibromopyridine Ethyl 4-hydroxy-3-oxobutanoate Dimethyl (2S)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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