ditazole
- CAS NO.：18471-20-0
- Empirical Formula: C19H20N2O3
- Molecular Weight: 324.37
- MDL number: MFCD00866073
- EINECS: 242-353-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:35
What is ditazole?
Originator
Ageroplas,Serona,Italy,1973
The Uses of ditazole
Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation.
Definition
ChEBI: Ditazole is a member of 1,3-oxazoles.
Manufacturing Process
A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The solvent was stripped at 1 mm and the oily residue was added at 60°C to 100 ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β- hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The product crystallized from ethyl ether + petroleum ether, with a MP of 96 to 98°C.
Therapeutic Function
Antiinflammatory
Trade name
Ageroplas (Lepori, Spain; Serono, Italy), Fendazol (Lepori, Portugal).
Mechanism of action
Ditazole is an anti-inflammatory analgesic agent that is of interest primarily for its ability to inhibit platelet aggregation. For example, it normalizes the enhanced platelet activity in cerebrovascular patients suffering transient ischemic attacks.
Synthesis
ditazole is prepared by heating 2-
chloro-4,5-diphenyloxazole and diethanolamine
in ethanol.
Properties of ditazole
| Melting point: | 100-101°C |
| Boiling point: | 505.5±60.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.08±0.10(Predicted) |
| color | White to Off-White |
Safety information for ditazole
Computed Descriptors for ditazole
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