Dioctadecylamine

Synonym(s):Distearylamine;DODA

CAS NO.：112-99-2
Empirical Formula: C36H75N
Molecular Weight: 521.99
MDL number: MFCD00048494
EINECS: 204-020-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:54:27

What is Dioctadecylamine?

The Uses of Dioctadecylamine

Dioctadecylamine (DODA) is suitable reagent used in the synthesis of the following:

Dioctadecylamine-BCN (bicyclo[6.1.0]nonyne) conjugate.
Lipid derivatives of bisethylnorspermine (BSP).
Functional VP (N-vinylpyrrolidone ) polymers.

It may be used in the following studies:

As a reactant in the synthesis of 4,4′-azobis(4-cyano-N,N-dioctadecyl)pentanamide (DODA-501) by reacting with disuccinimidyl 4,4′-azobis(4-cyanovalerate).
As a reagent in the synthesis of dioctadecyl heptapeptides.
As a phase transfer and stabilizer agent for gold nanoparticles (AuNPs) in non-polar solvent.

General Description

Dioctadecylamine (DODA), a secondary amine, is a fatty amine derivative. Its biodegradation potential has been assessed. It has been observed that in aqueous medium DODA self organizes into plate like structures. Its partial charge distribution as a function of its conformation has been analyzed. The phase diagram of dioctadecylamine Langmuir monolayers has been determined and investigations show it does not form a monolayer above pH 3.9. DODA has been utilized in forming liposomes, cationic lipids or lipid chelating agents.

Properties of Dioctadecylamine

Melting point:	71-73 °C
Boiling point:	524.75°C (estimate)
Density	0.9086 (estimate)
refractive index	1.4841 (estimate)
solubility	water: soluble(lit.)
pka	10.84±0.19(Predicted)
BRN	1801688
EPA Substance Registry System	1-Octadecanamine, N-octadecyl- (112-99-2)

Safety information for Dioctadecylamine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.