Dimethyl trimethylsilyl phosphite
- CAS NO.：36198-87-5
- Empirical Formula: C5H15O3PSi
- Molecular Weight: 182.23
- MDL number: MFCD00075439
- EINECS: 252-908-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:55:31
What is Dimethyl trimethylsilyl phosphite?
Chemical properties
clear colorless liquid
The Uses of Dimethyl trimethylsilyl phosphite
Dimethyl trimethylsilyl phosphite may be used in the preparation of:
- protected phosphoamino acid, Fmoc-Abu(PO3Me2)-OH, used in Fmoc/solid-phase peptide synthesis
- phosphoenolpyruvate (PEP) via trimethylsilylation, bromination and Perkow reaction
- sialyl phosphonate
- sulfonamide phosphonates
Properties of Dimethyl trimethylsilyl phosphite
| Boiling point: | 36-37 °C/11 mmHg (lit.) |
| Density | 0.954 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 102 °F |
| storage temp. | 2-8°C |
| Specific Gravity | 0.954 |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1849308 |
Safety information for Dimethyl trimethylsilyl phosphite
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Dimethyl trimethylsilyl phosphite
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