dihydroeponemycin
- CAS NO.：126463-64-7
- Empirical Formula: C20H36N2O6
- Molecular Weight: 400.51
- MDL number: MFCD17215971
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:53:48
What is dihydroeponemycin?
Description
Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It potently inhibits both the chymotrypsin-like and PGPH activity, with 10-fold less inhibition of trypsin-like activity. Dihydroeponemycin does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells.
Properties of dihydroeponemycin
| storage temp. | 2-8°C |
| solubility | DMSO: ≥1mg/mL |
| form | powder |
| color | off-white to light tan |
| optical activity | [α]/D ±35.7° |
Safety information for dihydroeponemycin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for dihydroeponemycin
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Dihydroeponemycin CAS 126463-64-7View Details
126463-64-7 -
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