dihydroeponemycin

CAS NO.：126463-64-7
Empirical Formula: C20H36N2O6
Molecular Weight: 400.51
MDL number: MFCD17215971
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:21

What is dihydroeponemycin?

Description

Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It potently inhibits both the chymotrypsin-like and PGPH activity, with 10-fold less inhibition of trypsin-like activity. Dihydroeponemycin does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells.

Properties of dihydroeponemycin

storage temp.	2-8°C
solubility	DMSO: ≥1mg/mL
form	powder
color	off-white to light tan
optical activity	[α]/D ±35.7°

Safety information for dihydroeponemycin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral

Computed Descriptors for dihydroeponemycin

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