Diethylacetamide
Synonym(s):Acetic acid diethylamide;N,N-Diethylacetamide
- CAS NO.：685-91-6
- Empirical Formula: C6H13NO
- Molecular Weight: 115.17
- MDL number: MFCD00009047
- EINECS: 211-685-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:26
What is Diethylacetamide?
Chemical properties
clear colorless liquid
The Uses of Diethylacetamide
N,N-Diethylacetamide was used to investigate the spectroscopic properties ofN,N-diethyl-2-[(4-substituted)phenylsulfinyl] acetamides. It is commonly used as drug solvent.
Synthesis Reference(s)
Chemistry Letters, 18, p. 1983, 1989
The Journal of Organic Chemistry, 59, p. 4035, 1994 DOI: 10.1021/jo00094a004
General Description
N,N-Diethylacetamide is commonly used as drug solvent.
Hazard
Toxic by ingestion.
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. Flammable when exposed to heat or flame. To fight fire, use foam, mist, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Dissolve the amide in cyclohexane, shake with anhydrous BaO and then filter. The procedure is repeated three times, and the cyclohexane is distilled off at atmospheric pressure. The crude amide is also fractionally distilled three times from anhydrous BaO. [Beilstein 4 III 349.]
Properties of Diethylacetamide
| Melting point: | <20 °C |
| Boiling point: | 182-186 °C (lit.) |
| Density | 0.925 g/mL at 25 °C (lit.) |
| vapor pressure | 1.2 hPa (25 °C) |
| refractive index | n |
| Flash point: | 159 °F |
| storage temp. | Store below +30°C. |
| solubility | 53.5g/l |
| form | clear liquid |
| pka | -0.41±0.70(Predicted) |
| color | Colorless to Almost colorless |
| Water Solubility | Soluble in water. |
| BRN | 1209428 |
| Dielectric constant | 31.329999999999998 |
| CAS DataBase Reference | 685-91-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide, N,N-diethyl-(685-91-6) |
| EPA Substance Registry System | N,N-Diethylacetamide (685-91-6) |
Safety information for Diethylacetamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Diethylacetamide
Diethylacetamide manufacturer
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