DIETHYL (CHLOROMETHYL)PHOSPHONATE
Synonym(s):Chloromethylphosphonic acid diethyl ester;NSC 67753
- CAS NO.：3167-63-3
- Empirical Formula: C5H12ClO3P
- Molecular Weight: 186.57
- MDL number: MFCD00010189
- EINECS: 221-632-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:16
What is DIETHYL (CHLOROMETHYL)PHOSPHONATE?
Chemical properties
Clear colorless to light yellow liquid
The Uses of DIETHYL (CHLOROMETHYL)PHOSPHONATE
Reactant involved in:
- Subsequent alkylation after nucleophilic substitution
- One-pot alkylation-boration of α-haloalkylphosphonates
- Synthesis of cyclpentane and pyrrolidine derivatives via regioselective insertion reactions
- Phosphorylation leading to P-containing cyclopropanes
- Wadsworth-Emmons reactions
- Ring expansion of zircnacycles via carbenoid insertion
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 3799, 1987 DOI: 10.1016/S0040-4039(00)96387-1
Properties of DIETHYL (CHLOROMETHYL)PHOSPHONATE
| Boiling point: | 109-110 °C10 mm Hg(lit.) |
| Density | 1.2 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 188 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.2 |
| BRN | 1363361 |
| EPA Substance Registry System | Phosphonic acid, (chloromethyl)-, diethyl ester (3167-63-3) |
Safety information for DIETHYL (CHLOROMETHYL)PHOSPHONATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DIETHYL (CHLOROMETHYL)PHOSPHONATE
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
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