DIETHYL (CHLOROMETHYL)PHOSPHONATE
Synonym(s):Chloromethylphosphonic acid diethyl ester;NSC 67753
- CAS NO.：3167-63-3
- Empirical Formula: C5H12ClO3P
- Molecular Weight: 186.57
- MDL number: MFCD00010189
- EINECS: 221-632-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:16
What is DIETHYL (CHLOROMETHYL)PHOSPHONATE?
Chemical properties
Clear colorless to light yellow liquid
The Uses of DIETHYL (CHLOROMETHYL)PHOSPHONATE
Reactant involved in:
- Subsequent alkylation after nucleophilic substitution
- One-pot alkylation-boration of α-haloalkylphosphonates
- Synthesis of cyclpentane and pyrrolidine derivatives via regioselective insertion reactions
- Phosphorylation leading to P-containing cyclopropanes
- Wadsworth-Emmons reactions
- Ring expansion of zircnacycles via carbenoid insertion
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 3799, 1987 DOI: 10.1016/S0040-4039(00)96387-1
Properties of DIETHYL (CHLOROMETHYL)PHOSPHONATE
| Boiling point: | 109-110 °C10 mm Hg(lit.) |
| Density | 1.2 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 188 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.2 |
| BRN | 1363361 |
| EPA Substance Registry System | Phosphonic acid, (chloromethyl)-, diethyl ester (3167-63-3) |
Safety information for DIETHYL (CHLOROMETHYL)PHOSPHONATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DIETHYL (CHLOROMETHYL)PHOSPHONATE
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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