Diethyl acetamidomalonate

Synonym(s):Acetamidomalonic acid diethyl ester

CAS NO.：1068-90-2
Empirical Formula: C9H15NO5
Molecular Weight: 217.22
MDL number: MFCD00009146
EINECS: 213-952-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-28 11:16:13

What is Diethyl acetamidomalonate?

Chemical properties

white to light yellow crystalline powder

The Uses of Diethyl acetamidomalonate

Diethyl 2-Acetamidomalonate, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin analogues as potential heat shock protein 90 inhibitors. It is also used as a important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals.

Safety Profile

An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the ester from *benzene/pet ether. [Beilstein 4 III 2993.]

Properties of Diethyl acetamidomalonate

Melting point:	95-98 °C (lit.)
Boiling point:	185 °C/20 mmHg (lit.)
Density	1.2850 (rough estimate)
refractive index	1.4640 (estimate)
Flash point:	185°C/20mm
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	11.93±0.59(Predicted)
form	Crystalline Powder
color	White to light yellow
Water Solubility	Soluble in chloroform and methanol. Slightly soluble in water.
BRN	783883
CAS DataBase Reference	1068-90-2(CAS DataBase Reference)
NIST Chemistry Reference	Propanedioic acid, (acetylamino)-, diethyl ester(1068-90-2)
EPA Substance Registry System	Propanedioic acid, 2-(acetylamino)-, 1,3-diethyl ester (1068-90-2)

Safety information for Diethyl acetamidomalonate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H290:Corrosive to Metals H314:Skin corrosion/irritation
Precautionary Statement Codes	P234:Keep only in original container. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P390:Absorb spillage to prevent material damage. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner.