Dibenzepin

Chemical properties

Crystalline Solid

Originator

Noveril ,Wander,Switz.,1965

The Uses of Dibenzepin

Antidepressant

Background

Dibenzepin is approved for use in Europe.

Definition

ChEBI: 5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone is a dibenzodiazepine.

What are the applications of Application

Dibenzepin is a norepinephrine reuptake inhibitor

Manufacturing Process

4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane. After adding a concentrated benzenic solution of β-dimethylamino-ethyl chloride freshly prepared from 3.75 grams of the hydrochloride with concentrated sodium hydroxide solution, taking up in benzene and drying the solution with potash, the mixture was boiled for 16 hours under reflux, whereupon the reaction mixture was concentrated to dryness and the residue distributed between ether and water. By exhaustive extraction of the basic fractions with dilute acetic acid, precipitation with ammonia, taking up the base in ether and working up the ethereal solution, there was obtained 5.05 grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11- dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous yellowish resin with the boiling point 185°C/0.01mm Hg. The base was crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of the monohydrochloride (from ethanol-ether) 234°-240°C.

Therapeutic Function

Psychostimulant

Metabolism

Not Available