Dianhydrogalactitol

Synonym(s):1,2:5,6-Dianhydrogalactitol;1,2:5,6-Diepoxydulcitol;DAG;NSC-132313;VAL-083

CAS NO.：23261-20-3
Empirical Formula: C6H10O4
Molecular Weight: 146.14
MDL number: MFCD01725532
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-11 16:31:51

What is Dianhydrogalactitol ?

The Uses of Dianhydrogalactitol

Dulcitol Diepoxide is a cytostatic drug. Dulcitol Diepoxide can be used for treatment of leukemia, lung cancer, multiple myeloma, and nasopharyngeal carcinoma.

Biological Activity

val-083 is a bi-functional alkylating agent, with potential antitumor activity.val-083 can cross the blood brain barrier and appears to be selective for tumor cells. val-083 alkylates and crosslinks dna which ultimately inhibit the proliferation of cancer cells. val-083 does not show cross-resistance to other conventional chemotherapeutic agents. the half-life of val-083 in the brain is long. val-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.

in vitro

VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h.

in vivo

VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. It (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.

References

http://www. delmarpharma.com/product_development_programs/val083/

Properties of Dianhydrogalactitol

Melting point:	96.5-98.5 °C
Boiling point:	185.74°C (rough estimate)
Density	1.567
refractive index	1.4310 (estimate)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Powder
pka	13.53±0.20(Predicted)
color	White to off-white