DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE
Synonym(s):N,N-Bis(1-methylethyl)phosphoramidous acid di-2-propenyl ester;Diallyloxy(diisopropylamino)phosphine
- CAS NO.：126429-21-8
- Empirical Formula: C12H24NO2P
- Molecular Weight: 245.3
- MDL number: MFCD00216647
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:07:09
What is DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE?
The Uses of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE
Diallyl N,N-diisopropylphosphoramidite is a reagent used in the synthesis of Leustroducsin B that exhibits large variety of biological activities. It also acts as a reagent in the synthesis of water-soluble prodrugs of triazole CS-758 with antifungal activities.
The Uses of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE
Precursor involved in the synthesis of pharmacologically active molecules including:• ;Selective orally active S1P1 agonists1• ;Water-soluble prodrugs of triazole CS-758 with antifungal activity2• ;Fostriecin analogs as antitumor agents3Reactant involved in: • ;Phosphitylation of alcohols4• ;Deallylation for the synthesis of nucleoside phosphoramidite5• ;Posphitylation and stereoselective Pudovik rearrangement6
The Uses of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE
Precursor involved in the synthesis of pharmacologically active molecules including:
- Selective orally active S1P1 agonists
- Water-soluble prodrugs of triazole CS-758 with antifungal activity
- Fostriecin analogs as antitumor agents
Reactant involved in:
- Phosphitylation of alcohols
- Deallylation for the synthesis of nucleoside phosphoramidite
- Posphitylation and stereoselective Pudovik rearrangement
Properties of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE
| Boiling point: | 130 °C(lit.) |
| Density | 0.928 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 90 °F |
| storage temp. | 2-8°C |
| pka | 4.96±0.70(Predicted) |
| BRN | 4383514 |
Safety information for DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE
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