DGAT-1 inhibitor
Synonym(s):DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem
- CAS NO.：959122-11-3
- Empirical Formula: C26H24N2O4
- Molecular Weight: 428.48
- MDL number: MFCD12828780
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-14 16:49:18
What is DGAT-1 inhibitor?
The Uses of DGAT-1 inhibitor
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
What are the applications of Application
A 922500 is a DGAT-1 (diacyl glycerolacyltransferase 1) inhibitor
Definition
ChEBI: A 922500 is an aromatic ketone.
Biological Activity
Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.
Biochem/physiol Actions
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
Properties of DGAT-1 inhibitor
| Density | 1.323 |
| storage temp. | -20°C |
| solubility | ≥21.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | Light yellow solid |
Safety information for DGAT-1 inhibitor
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Environment GHS09 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H319:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P501:Dispose of contents/container to..… |
Computed Descriptors for DGAT-1 inhibitor
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