DFMO
- CAS NO.：66640-93-5
- Empirical Formula: C6H12F2N2O2
- Molecular Weight: 182.17
- MDL number: MFCD00221766
- Update Date: 2026-03-18 11:52:23
What is DFMO?
Biological Activity
L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1.
in vivo
The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.
Properties of DFMO
| Boiling point: | 347.0±42.0 °C(Predicted) |
| Density | 1.293±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 1.22±0.44(Predicted) |
Safety information for DFMO
Computed Descriptors for DFMO
New Products
2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]- 3-(4-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione 4-Hydroxy-6-methyl-1-(4-methylphenyl)-2-naphthalenecarboxylic acid 2,3-Difluoro-6-methoxybenzyl Chloride KT-474 2-(6-(benzyloxy)-3,4-dihydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3-Oxocyclobutanecarboxylic acid 5-Bromo-2-iodo pyridine Benzofuran-6-carboxylic acid (BFA) 3-Bromo-2-Ethoxy-5-Nitropyridine 3,6-Dichloro-2-Methylpyridine 2-Amino-5-Bromo-3-IodopyridineRelated products of tetrahydrofuran
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