Desmethyl loperamide
- CAS NO.：66164-07-6
- Empirical Formula: C28H31ClN2O2
- Molecular Weight: 463.01
- MDL number: MFCD08063667
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-11-04 16:50:46
What is Desmethyl loperamide?
Chemical properties
Off-White Solid
The Uses of Desmethyl loperamide
A metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function
The Uses of Desmethyl loperamide
Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. N-Desmethyl-loperamide (dLop) is a major metabolite of loperamide. Like loperamide, dLop is a substrate of the ATP-dependent efflux transporter, P-glycoprotein. As a result, both the parent compound and the metabolite display restricted passage through the blood-brain barrier. dLop in biological samples can be analyzed by a variety of methods.
What are the applications of Application
N-Desmethyl Loperamide is a metabolite of Loperamide
Definition
ChEBI: A monocarboxylic acid amide that is the methylamide of 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanoic acid.
Properties of Desmethyl loperamide
| Melting point: | 219-221?C |
| Boiling point: | 678.3±55.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMF: 2 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml |
| form | A crystalline solid |
| pka | 13.85±0.20(Predicted) |
Safety information for Desmethyl loperamide
Computed Descriptors for Desmethyl loperamide
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 4-(4-Αminophenyl)-3-Morpholinone 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one N-cyanoacetylurethane 1H-IndazoleRelated products of tetrahydrofuran
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