DEHYDROABIETYLAMINE
Synonym(s):1,4a-Dimethyl-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenemethylamine
- CAS NO.：1446-61-3
- Empirical Formula: C20H31N
- Molecular Weight: 285.47
- MDL number: MFCD06795849
- EINECS: 215-899-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:17
What is DEHYDROABIETYLAMINE?
Chemical properties
clear yellow viscous liquid
The Uses of DEHYDROABIETYLAMINE
Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans.
What are the applications of Application
Leelamine HCl is a weak CB1 receptor agonist and PDK inhibitor
Definition
ChEBI: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine is a diterpenoid.
Biological Activity
CB 1 agonist. Displaces binding of [ 3 H]-SR141716A with an IC 50 value of 2.86 μ M.
Purification Methods
The crude base is purified by converting 2g of base in toluene (3.3mL) into the acetate salt by heating at 65-70o with 0.46g of AcOH, and the crystals are collected and dried (0.96g from two crops, m 141-143o). The acetate salt is dissolved in warm H2O, basified with aqueous NaOH and extracted with *C6H6. The dried extract (MgSO4) is evaporated in vacuum leaving a viscous oil which crystallises and can be distilled. [Gottstein & Cheney J Org Chem 30 2072 1965.] The picrate has m 234-236o (from aqueous MeOH), and the formate has m 147-148o (from heptane). [Beilstein 12 IV 3005.]
Properties of DEHYDROABIETYLAMINE
| Melting point: | 44.50℃ |
| Boiling point: | 417.89°C (rough estimate) |
| Density | 0.963±0.06 g/cm3 (20 ºC 760 Torr) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, DMSO, Methanol |
| form | White solid. |
| pka | 10.13±0.29(Predicted) |
| color | Pale Yellow |
| optical activity | [α]20/D +56.1°, c = 2.4 in pyridine |
| BRN | 3084620 |
| CAS DataBase Reference | 1446-61-3(CAS DataBase Reference) |
| EPA Substance Registry System | Dehydroabietylamine (1446-61-3) |
Safety information for DEHYDROABIETYLAMINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DEHYDROABIETYLAMINE
DEHYDROABIETYLAMINE manufacturer
Triveni Interchem Private Limited (Group Of Triveni Chemicals)
Gujarat
product: Dehydroabietylamine, Packaging Type: Drum
GLR Innovations
4Y
Beijing
product: DEHYDROABIETYLAMINE a PDK pyruvate dehydrogenase kinase inhibitor
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![[(1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDRO-1-PHENANTHRENYL]-N-(4-METHOXY-2,5-DIMETHYLBENZYL)METHANAMINE HYDROCHLORIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure8/GIF/CB5397851.gif)
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