DCPIB
- CAS NO.：82749-70-0
- Empirical Formula: C22H28Cl2O4
- Molecular Weight: 427.36
- MDL number: MFCD07783995
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:08
What is DCPIB?
The Uses of DCPIB
DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells.
What are the applications of Application
DCPIB is a selective and potent blocker of VSAC and inhibitor of glucose-stimulated insulin release.
Definition
ChEBI: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid is a member of indanones.
Biological Activity
Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro .
Storage
Store at +4°C
Properties of DCPIB
| Boiling point: | 593.8±50.0 °C(Predicted) |
| Density | 1.262±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | insoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO |
| form | solid |
| pka | 4.53±0.10(Predicted) |
| color | White |
Safety information for DCPIB
Computed Descriptors for DCPIB
New Products
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