dBET6

CAS NO.：1950634-92-0
Empirical Formula: C42H45ClN8O7S
Molecular Weight: 841.37
MDL number: MFCD31692407
Update Date: 2026-07-14 16:49:18

What is dBET6?

Description

dBET6 is a potent, selective, and cell-permeable PROTAC connected by ligands for Cereblon and BET and has antitumor activity.

Definition

ChEBI: DBET6 is an organic molecular entity.

Biological Activity

dBET6 is a BET bromodomains PROTAC degrader with good cell permeability, binding to BRD4 with an IC50 of 14 nM. It also induces down-regulation and apoptosis of c-MYC.

Storage

Store at -20°C

Properties of dBET6

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:60.0(Max Conc. mg/mL);71.32(Max Conc. mM) Ethanol:35.0(Max Conc. mg/mL);41.6(Max Conc. mM)
form	A solid
pka	10.68±0.40(Predicted)
color	White to light yellow

Safety information for dBET6

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for dBET6

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