DBCO-PEG4-NH-Boc

CAS NO.：1255942-12-1
Empirical Formula: C34H45N3O8
Molecular Weight: 623.74
MDL number: MFCD30730371
Update Date: 2026-05-28 00:28:59

What is DBCO-PEG4-NH-Boc?

Description

DBCO-NHCO-PEG4-NH-Boc is a click chemistry reagent. it can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions.

Biological Activity

DBCO-NHCO-PEG4-NH-Boc is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Properties of DBCO-PEG4-NH-Boc

Boiling point:	840.5±65.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
form	Viscous Liquid
pka	12.23±0.46(Predicted)
color	Colorless to yellow

Safety information for DBCO-PEG4-NH-Boc

Computed Descriptors for DBCO-PEG4-NH-Boc

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