Daun02

CAS NO.：290304-24-4
Empirical Formula: C41H44N2O20
Molecular Weight: 884.79
MDL number: MFCD22124459
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:12

What is Daun02?

Biological Activity

daun02 is an inhibitor of cell viability with ic50 values of 1.5μm, 3.5μm and 0.5μm, respectively in panc02, mcf-7 and t47-d cell lines [1].daun02, an anthracycline derivative, is a substrate of β-galactosidase. β-galactosidase catalyses daun02 into daunomycin, which causes apoptotic cell death and blockade of voltagedependent calcium channels. daun02 has been used in the study of suicide gene therapy which has thepotential to increase the selective toxicityof conventional antitumor agents. in this study, daun02 is shown to suppress the viability of several β-gal gene transduced tumor celllinesin vitro. however, none of thetumors responded to treatment withdaun02in vivo. this mayhave been due tothe limited aqueous solubilityof the agent.daun02 is also used to study activated neuronal ensembles in models of conditioned drug effects and relapse. the method is called daun02 inactivation method. in the fos–lacz transgenic rats, the previously drug activated neurons can be inactivated through injection of the prodrug daun02 [1,2].carl r. lupica, yavinshaham and bruce t. hope.new technologies for examining the role of neuronal ensembles in drug addiction and fear.nature reviews/neuroscience. 2013, 14: 743-754.

in vitro

Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca ²⁺ )-dependent action potentials in neuroblastoma cells. Daunorubicin is a topoisomerase inhibitor.It is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC ₅₀ ) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively.

in vivo

Daun02 is a good substrate for β-gal with K _m and V _max values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10 ^-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin.

References

[1] david farquhar, bih fang pan, mamoru sakurai, ajitghosh, craig a. mullen, j. arly nelson. suicide gene therapy using e.coliβ-galactosidase. cancer chemotherpharmacol.2002, 50: 65–70.
[2] fabio c. cruz, eisukekoya, danielle h. guez-barber, jennifer m. bossert,

Properties of Daun02

Boiling point:	1128.4±65.0 °C(Predicted)
Density	1.67±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥17.92 mg/mL in DMSO with ultrasonic
form	Powder
pka	7.39±0.60(Predicted)
color	Brown to wine

Safety information for Daun02

Computed Descriptors for Daun02

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