Daltroban

Synonym(s):4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid;BM-13505;SKF-96148

CAS NO.：79094-20-5
Empirical Formula: C16H16ClNO4S
Molecular Weight: 353.82
MDL number: MFCD00868295
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is Daltroban?

Description

Daltroban (BM 13505, SKF 96148), a specific thromboxane A2 receptor antagonist, was studied as an antithrombotic agent. Daltroban increases intracellular calcium in vascular smooth muscle cells. Daltroban shows a protective effect in reperfusion injury. The drug was licensed to Smith Kline Beecham and underwent phase III clinical trials in the UK and Germany as an antithrombotic agent but did not enter clinical trials in the USA. Besides, вaltroban was investigated in patients with an ischemic heart disorder. However, the development of daltroban has been discontinued.

The Uses of Daltroban

Daltroban can be used as a2 receptor to target adipose-derived stem cell for treating ischemic diseases.

The Uses of Daltroban

Immunosuppressant.

The Uses of Daltroban

Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist that increases intracellular calcium ions in vascular smooth muscle cells and protects against reperfusion injury after myocardial ischaemia but not in coronary artery endothelial cells. Daltroban may also be useful in the treatment of patients with COPD-related pulmonary hypertension.

What are the applications of Application

Daltroban is selective TXA2R (thromboxane A2 receptor) antagonist

Properties of Daltroban

Melting point:	132.5-137.4 °C(lit.)
Boiling point:	555.3±60.0 °C(Predicted)
Density	1.378±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 22 mg/mL, soluble
pka	4.33±0.10(Predicted)
form	A solid
color	white
InChI	InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
CAS DataBase Reference	79094-20-5(CAS DataBase Reference)

Safety information for Daltroban

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.