Daltroban
Synonym(s):4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid;BM-13505;SKF-96148
- CAS NO.：79094-20-5
- Empirical Formula: C16H16ClNO4S
- Molecular Weight: 353.82
- MDL number: MFCD00868295
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is Daltroban?
Description
Daltroban (BM 13505, SKF 96148), a specific thromboxane A2 receptor antagonist, was studied as an antithrombotic agent. Daltroban increases intracellular calcium in vascular smooth muscle cells. Daltroban shows a protective effect in reperfusion injury. The drug was licensed to Smith Kline Beecham and underwent phase III clinical trials in the UK and Germany as an antithrombotic agent but did not enter clinical trials in the USA. Besides, вaltroban was investigated in patients with an ischemic heart disorder. However, the development of daltroban has been discontinued.
The Uses of Daltroban
Daltroban can be used as a2 receptor to target adipose-derived stem cell for treating ischemic diseases.
The Uses of Daltroban
Immunosuppressant.
The Uses of Daltroban
Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist that increases intracellular calcium ions in vascular smooth muscle cells and protects against reperfusion injury after myocardial ischaemia but not in coronary artery endothelial cells. Daltroban may also be useful in the treatment of patients with COPD-related pulmonary hypertension.
What are the applications of Application
Daltroban is selective TXA2R (thromboxane A2 receptor) antagonist
Properties of Daltroban
| Melting point: | 132.5-137.4 °C(lit.) |
| Boiling point: | 555.3±60.0 °C(Predicted) |
| Density | 1.378±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 22 mg/mL, soluble |
| pka | 4.33±0.10(Predicted) |
| form | A solid |
| color | white |
| InChI | InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20) |
| CAS DataBase Reference | 79094-20-5(CAS DataBase Reference) |
Safety information for Daltroban
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Daltroban
| InChIKey | IULOBWFWYDMECP-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC=C(CCNS(C2=CC=C(Cl)C=C2)(=O)=O)C=C1 |
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