Dacarbazine
Synonym(s):5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide;Dacarbazine;DTIC
- CAS NO.:4342-03-4
- Empirical Formula: C6H10N6O
- Molecular Weight: 182.18
- MDL number: MFCD00057167
- EINECS: 224-396-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-10 17:26:08
![Dacarbazine Structural](https://img.chemicalbook.in/CAS/GIF/4342-03-4.gif)
What is Dacarbazine?
Absorption
Erratic, slow and incomplete.
Toxicity
LD50=350mg/kg (orally in mice)
Description
Dacarbazine is nevertheless considered the first representative of the series of triazene derivatives. It has been shown that it is an alkylating agent, and thus this drug inhibits RNA and protein synthesis to a greater degree than DNA. Dacarbazine is used intravenously for Hodgkin’s disease, soft-tissue sarcoma, and metastatic melanoma. A synonym of this drug is diticene.
The Uses of Dacarbazine
Dacarbazine is used as an antineoplastic for treatment of malignant melanoma and sarcomas.
Background
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Indications
For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
What are the applications of Application
Dacarbazine is appears to exert cytotoxic effects
Pharmacokinetics
Dacarbazine is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). After intravenous administration of dacarbazine, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours. 1 In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours. 1 The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. 1 DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations dacarbazine is not appreciably bound to human plasma protein.
Metabolism
Hepatic
Properties of Dacarbazine
Melting point: | 199-205°C |
Boiling point: | 315.57°C (rough estimate) |
Density | 1.3206 (rough estimate) |
storage temp. | 2-8°C |
solubility | Slightly soluble in water and in anhydrous ethanol, practically insoluble in methylene chloride. |
form | powder |
color | Off-White to Light Yellow |
Water Solubility | Slightly soluble in water, DMSO and ethanol
/n |
Safety information for Dacarbazine
Signal word | Danger |
Pictogram(s) |
![]() Exclamation Mark Irritant GHS07 ![]() Health Hazard GHS08 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H340:Germ cell mutagenicity H350:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Dacarbazine
Abamectin manufacturer
Basil Drugs AND Pharmaceuticals Pvt Ltd
Mac Chem Products (India) Pvt Ltd (Naprod Group)
Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd)
Myosynth Laboratories Pvt Ltd
Kekule Life Sciences Limited
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