D8-MMAE

CAS NO.：2070009-72-0
Empirical Formula: C39H59D8N5O7
Molecular Weight: 726.027874224
MDL number: MFCD28386277
Update Date: 2026-07-16 07:06:08

What is D8-MMAE?

Biological Activity

D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE. MMAE is a tubulin inhibitor that inhibits mitosis.

in vivo

Intratumoral MMAE concentrations consistently correlates with the extent of tumor growth inhibition in tumor xenograft models. IHC analysis reveals that nonbinding control-treated tumors consist of both CD30 ⁺ and CD30 ^- cells, presumably because they do not kill either CD30 ⁺ or CD30 ^- Karpas 299 cells. Only CD30 ^- cells are found in cAC10-vcMMAF-treated tumors, illustrating that cAC10-vcMMAF eliminates most CD30 ⁺ cells. Interestingly, the two tumors that relapses from cAC10-vcMMAE treatment are also found to be CD30 ^- by the end of study, indicating a small fraction of CD30 ^- cells might have escaped from bystander killing in these two remaining tumors.

Properties of D8-MMAE

storage temp.	Store at -20°C,unstable in solution, ready to use.
solubility	DMSO : 100 mg/mL (137.74 mM; Need ultrasonic)
form	Solid
color	White to off-white

Safety information for D8-MMAE

Computed Descriptors for D8-MMAE

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