D-Serine, N-[[2-(2,1,3-benzoxadiazol-5-ylmethoxy)-4-[(2-bromo[1,1'-biphenyl]-3-yl)methoxy]-5-chlorophenyl]methyl]-, ethyl ester, hydrochloride (1:1)

CAS NO.：2597056-04-5
Empirical Formula: C32H30BrCl2N3O6
Molecular Weight: 703.41
Update Date: 2025-04-17 18:22:24

What is D-Serine, N-[[2-(2,1,3-benzoxadiazol-5-ylmethoxy)-4-[(2-bromo[1,1'-biphenyl]-3-yl)methoxy]-5-chlorophenyl]methyl]-, ethyl ester, hydrochloride (1:1)?

Biological Activity

PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester prodrug of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice[1].

References

[1]. Liu L, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021;64(12):8391-8409.

Properties of D-Serine, N-[[2-(2,1,3-benzoxadiazol-5-ylmethoxy)-4-[(2-bromo[1,1'-biphenyl]-3-yl)methoxy]-5-chlorophenyl]methyl]-, ethyl ester, hydrochloride (1:1)

storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (355.41 mM; Need ultrasonic)
form	Solid
color	White to off-white

Safety information for D-Serine, N-[[2-(2,1,3-benzoxadiazol-5-ylmethoxy)-4-[(2-bromo[1,1'-biphenyl]-3-yl)methoxy]-5-chlorophenyl]methyl]-, ethyl ester, hydrochloride (1:1)

Computed Descriptors for D-Serine, N-[[2-(2,1,3-benzoxadiazol-5-ylmethoxy)-4-[(2-bromo[1,1'-biphenyl]-3-yl)methoxy]-5-chlorophenyl]methyl]-, ethyl ester, hydrochloride (1:1)

New Products

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