D-MANNOHEPTULOSE
Synonym(s):D -Manno-2-heptulose
- CAS NO.：3615-44-9
- Empirical Formula: C7H14O7
- Molecular Weight: 210.18
- MDL number: MFCD00037814
- EINECS: 222-795-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:58
What is D-MANNOHEPTULOSE?
Description
D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose.
Chemical properties
White Solid
The Uses of D-MANNOHEPTULOSE
Mannoheptulose occurs naturally in avocado fruit.
The Uses of D-MANNOHEPTULOSE
Mannoheptulose occurs naturally in avocado fruit. It is used for normalizing insulin levels and reducing weight.
What are the applications of Application
D-Mannoheptulose is a hexokinase inhibitor that blocks glucose phosphorylation
Definition
ChEBI: D-keto-manno-heptulose is the open chain form of D-manno-heptulose.
Properties of D-MANNOHEPTULOSE
| Melting point: | 148-150°C |
| Boiling point: | 628.0±55.0 °C(Predicted) |
| alpha | D20 +29° (c = 2 in H2O) |
| Density | 1.645±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 11.86±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| Merck | 13,4686 |
| BRN | 1726433 |
| EPA Substance Registry System | D-manno-2-Heptulose (3615-44-9) |
Safety information for D-MANNOHEPTULOSE
Computed Descriptors for D-MANNOHEPTULOSE
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