D-Alanine

Synonym(s):(R)-2-Aminopropionic acid

CAS NO.：338-69-2
Empirical Formula: C3H7NO2
Molecular Weight: 89.09
MDL number: MFCD00008077
EINECS: 206-418-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-02-27 08:50:14

What is D-Alanine?

Chemical properties

White Crystalline Powder

The Uses of D-Alanine

D-Alanine is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls.

What are the applications of Application

D-Alanine is a weak inhibitory glycine receptor agonist

Definition

ChEBI: The D-enantiomer of alanine.

What are the applications of Application

D-Alanine is a LHRH-antagonists, e.g., Abarelix (antineoplas- tic)

General Description

Alanine is a non essential amino acid.

Biochem/physiol Actions

D-Alanine is the non-proteinogenic form of alanine which is used in bacterial cell wall biosynthesis. D-Alanine is used to study the specificity and kinetics of alanine racemase(s) (alaR).

Purification Methods

Crystallise alanine from H2O or aqueous EtOH, i.e. crystallise it from 25% EtOH in water, or recrystallise it from 62.5% EtOH, wash it with EtOH and dry it to constant weight in vacuo over P2O5. [Gutter & Kegeles J Am Chem Soc 75 3893 1953, Walsh J Biol Chem 264 2394 1989.] 2,2'-Iminodipropionic acid is a likely impurity. [Beilstein 4 IV 2480. 2481.]

Properties of D-Alanine

Melting point:	291 °C (dec.)(lit.)
Boiling point:	212.9±23.0 °C(Predicted)
alpha	-14.5 º (c=10, 6N HCl)
Density	1.4310 (estimate)
refractive index	-14 ° (C=2, 6mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	H2O: soluble
form	Crystalline Powder or Crystals
pka	2.31±0.10(Predicted)
color	White to off-white
Odor	odorless
Water Solubility	155 g/L (20 ºC)
Merck	14,204
BRN	1720249
CAS DataBase Reference	338-69-2(CAS DataBase Reference)
NIST Chemistry Reference	D-Alanine(338-69-2)
EPA Substance Registry System	D-Alanine (338-69-2)

Safety information for D-Alanine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.